Top 3 Cancers Affecting Women In The USA
Here are the top 3 cancers affecting women in the U.S. today, listed by prevalence (incidence) among women, and some details for each.
1. Breast cancer






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Breast cancer is the most common cancer diagnosed among U.S. women (excluding non-melanoma skin cancers). (American Cancer Society)
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Lifetime risk: About 1 in 8 women (~13 %) will develop invasive breast cancer in their lifetime. (National Breast Cancer Foundation)
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Incidence: For 2025, estimates are about 316,950 new cases of invasive breast cancer among women in the U.S. (Breastcancer.org)
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It’s the second-leading cause of cancer death for women (after lung cancer) though survival has improved substantially. (CDC)
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Key Notes: Risk increases with age; family history and certain gene mutations (e.g., BRCA1/BRCA2) play a role; early detection (mammograms, awareness) makes a big difference. (Breastcancer.org)
2. Lung cancer
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Lung cancer is the second most common cancer diagnosed among women (excluding non-melanoma skin cancer). (American Cancer Society)
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Estimated new cases in women in 2025: ~115,970 women in the U.S. will be diagnosed with lung cancer. (Lung Cancer Research Foundation)
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Lifetime risk of developing lung cancer: For women approximately 1 in 18. (American Cancer Society)
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It is the leading cause of cancer death for women (i.e., although breast cancers are more common, lung cancer kills more women). (American Cancer Society)
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Key Notes: Smoking is the predominant risk factor, but a significant number of women who develop lung cancer are non-smokers. Women face some distinct risk profiles and may be under-recognized. (LUNGevity Foundation)
3. Colorectal cancer (Colon & Rectal Cancer)






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Colorectal cancer is among the top three most commonly diagnosed cancers in U.S. women (in terms of incidence) after breast and lung. (Mass General Brigham)
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Lifetime risk for women: about 1 in 26 will develop colorectal cancer in their lifetime. (American Cancer Society)
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Incidence: According to SEER data, for 2018-2022, new cases among women (age‐adjusted) were ~32.6 per 100,000 for females. (SEER)
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Key Notes: Screening (colonoscopy, stool tests) and lifestyle factors (diet, activity, weight) strongly affect risk. Worryingly, incidence among younger adults is rising. (Cancer Research Institute)
Summary Table
| Rank | Cancer Type | Why it’s high in women |
|---|---|---|
| 1 | Breast cancer | Most common in women; high incidence; strong screening awareness makes big impact |
| 2 | Lung cancer | Very high mortality; second most common diagnosis in women; unique risk context |
| 3 | Colorectal cancer | High incidence and significant burden; screening essential; rising among younger women |
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